[KO Validated] TXLNA Rabbit pAb - P40222

Core Product Specifications and Parameters

Biological Background: TXLNA Function and Localization

• Protein identity: TXLNA encodes alpha-taxilin, a coiled‑coil domain‑containing protein belonging to the taxilin family. Alternative names include IL14 and TXLN.
• Vesicle trafficking: Alpha-taxilin is proposed to participate in intracellular vesicle traffic, potentially regulating the movement and docking of transport vesicles.
• Neuroendocrine exocytosis: Functional evidence suggests a role in calcium‑dependent exocytosis within neuroendocrine cells, where it may facilitate secretory granule fusion and release.
• Subcellular distribution: The protein is ubiquitously expressed, with markedly higher levels detected in heart, kidney, liver, and pancreas.
• Post‑translational modification: Classified as a phosphoprotein, indicating that its activity or interactions could be regulated by phosphorylation.
• Proteomics annotation: Identified as a reference proteome component in mass‑spectrometry‑based proteomics studies.
• Structural features: Contains coiled‑coil regions that likely mediate protein–protein interactions, consistent with its role in tethering organelles or vesicles.

Experimental Guidance and Technical Tips

• The immunogen (aa 1–160 of human TXLNA) covers an N‑terminal region that may be conserved; verify specificity in knockout‑validated systems.
• This polyclonal antibody is suitable for western blotting (WB) and ELISA; for novel applications such as immunofluorescence or immunoprecipitation, empirical validation is advised.
• Detect alpha‑taxilin in human samples; cross‑reactivity with other species has not been tested, so consider species‑matched controls if extending beyond human.
• Store aliquots at −20 °C upon arrival (shipped on ice bags) to maintain stability, and avoid repeated freeze–thaw cycles.

CamelBio: Your One‑Stop Sourcing Bridge

CamelBio empowers diagnostic manufacturers and research laboratories with reliable access to IVD raw materials, including validated antibody pairs and optimized polyclonal antibodies like this anti‑TXLNA reagent. Whether you require bulk ancillary reagents or assistance in sourcing rare target tools for vesicle trafficking and exocytosis studies, our supply network supports seamless progression from early‑stage research to clinical application.