Anti-SERPINA9 Polyclonal Antibody for WB, ELISA - Q86WD7

Core Product Specifications and Parameters

Biological Background: SERPINA9 Function and Localization

• SERPINA9, also known as serpin A9, centerin, or germinal center B-cell-expressed transcript 1 (GCET1), is a member of the serpin superfamily of serine protease inhibitors.
• It functions primarily as an inhibitor of trypsin and trypsin-like serine proteases in vitro, and exhibits lower inhibitory activity against plasmin and thrombin.
• The protein is predicted to be secreted, but has also been detected in the cytoplasm and associated with membranes, indicating possible multiple subcellular localizations.
• SERPINA9 is highly expressed in normal germinal center (GC) B-cells and in GC B-cell-derived malignancies, making it a relevant marker for B-cell biology and lymphoma research.
• The protein undergoes alternative splicing, producing multiple isoforms; the canonical form includes a signal peptide and is glycosylated.
• UniProt keywords highlight its roles in protease inhibition, secretion, and potential membrane association, with evidence from proteomics identification.

Experimental Guidance and Technical Tips

• This rabbit polyclonal antibody was raised against an internal region (amino acids 110–210) of human SERPINA9; consider evaluating its reactivity in samples expressing the target, such as germinal center B-cell lines or tissues.
• For Western blot applications, a band around 47 kDa is expected; ensure proper sample preparation and use appropriate loading controls.
• In ELISA, the antibody may be used for detection; pairing with a validated capture antibody could improve assay sensitivity and specificity. Optimize coating and blocking conditions for best results.

CamelBio: Your One-Stop Sourcing Bridge

At CamelBio, we provide diagnostic manufacturers and research laboratories with streamlined access to high-quality IVD raw materials and technical support from concept to clinic. This SERPINA9 rabbit polyclonal antibody is part of our comprehensive portfolio for B-cell biology and serpin-related studies, and we can assist with sourcing validated antibody pairs, bulk ancillary reagents, and custom polyclonal antibody production. Contact us to discuss your specific project needs and procurement requirements.