Anti-ADIPOR2 Polyclonal Antibody for WB, ELISA - Q86V24

Core Product Specifications and Parameters

Biological Background: ADIPOR2 Function and Localization

• ADIPOR2 (Adiponectin receptor protein 2, also known as PAQR2 or progestin and adipoQ receptor family member 2) is a member of the progestin and adipoQ receptor (PAQR) family.
• It functions as a receptor for ADIPOQ (adiponectin), a key hormone in regulating glucose and lipid metabolism. ADIPOQ binding triggers a cascade that enhances PPARA activity, promoting fatty acid oxidation and glucose uptake. Related references: PMID:12802337, PMID:25855295
• Plays a critical role in maintaining normal body fat and glucose homeostasis; required for proper revascularization after chronic ischemia.
• Localized to the cell membrane as a multi-pass transmembrane protein with a zinc-binding site.
• Exhibits intermediate binding affinity for both globular and full-length adiponectin.
• Ubiquitously expressed, with highest levels in skeletal muscle, liver, and placenta; weakly detected in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes, and lung.

Experimental Guidance and Technical Tips

• The immunogen (aa 1–147) encompasses the extracellular N‑terminus; the antibody may preferentially recognize the receptor’s extracellular domain in membrane preparations.
• For WB, denature lysates under reducing conditions and probe for a band at ~44kDa. Skeletal muscle, liver, or placenta from human, mouse, or rat serve as suitable positive controls.
• In ELISA, direct coating with recombinant ADIPOR2 protein or the immunogen peptide may be employed; consider pairing with a detection antibody for sandwich formats.
• Polyclonal antibodies can exhibit batch-to-batch variability; include appropriate controls (blocking peptide, siRNA knockdown) to confirm specificity in your experimental system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research institutes with one-stop access to validated IVD raw materials, including this anti-ADIPOR2 polyclonal antibody, bulk ancillary reagents, and support for rare‑target sourcing. Our integrated supply chain streamlines metabolic assay development—from antibody selection to final validation—so you can focus on translating research into reliable diagnostics.