rapid test
Interleukin-6 (IL-6) inflammatory rapid test
Item Number : IL-6
Price varies based on specs and customizations
- Diseases
- inflammatory
- Application
- rapid test
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Product Overview Table
| Feature | Description |
|---|---|
| Product Name | IL-6 |
| Host Species | Mouse |
| Application | LF, FIA |
| Dosage Form/Appearance | Liquid, may turn slightly opaque during storage |
| Concentration | 5.0 mg/ml (+/- 10 %) |
| Antibody Subtype | IgG1 |
| Clonality | Monoclonal |
| Antigen Epitope | N/D |
| Purity | ≥ 95 % |
| Affinity Constant | KA= 1.3 x 1011 1/M; KD= 7.7 x 10-11 M (=0.08 nM), BLI (Octet RED96e) |
| Related Products | Recombinant IL-6 antigen, Medix Biochemica 710015, 710039, 710038 and recombinant IL-6 antigen Lee Biosolutions 341-36. |
| Buffer | 50 mM Na-citrate, pH 6.0, 0.9 % NaCl, 0.095 % NaN3 as a preservative |
| Isoelectric Point | 6.3–7.6 |
| Cross-Reactivity | N/D |
| Specificity | Antibody recognizes human interleukin-6 (IL-6) |
| Shelf life | 24 months |
Storage and Transportation Conditions Table
| Condition | Description |
|---|---|
| Storage Conditions | +2-8°C |
| Transportation Conditions | Cold packs |
Finished Product Performance Indicator Table
| Indicator | Requirement |
|---|---|
| Package Appearance | Product outer packaging box, aluminum foil packaging bag should be intact and undamaged. |
| Detection Buffer Appearance | Clear and transparent, free of suspended matter. The tube should be well sealed, without leakage. |
| Detection Buffer Volume | The filling volume of the buffer should be 1.0mL, and its net content should be within the range of 1.0g±0.05g. |
| Detection Buffer pH | The pH of the buffer should be within the range of 7.2±0.2. |
| Test Strip Appearance | Clean and flat, no burrs, no damage, no pollution; the material should be firmly attached. |
| Test Strip Width | The width should not exceed ±0.80mm of the nominal value, and the nominal value is 4.50mm. |
| Migration Rate | The migration rate of the liquid should not be less than 10mm/min. |
| Minimum Detection Limit | IL-6 should not be higher than 5 Pg/L. |
| Linear Range | IL-6: Within the range of 5pg/L~2000.0pg/L, the linear correlation coefficient r≥0.990. |
| Accuracy | Relative deviation should not be greater than 20%. |
| Repeatability | Repeatability should not be greater than 10%. |
| Batch-to-batch Precision (Inter-batch Difference) | Inter-batch difference should not be greater than 15%. |
| Stability Testing | The product should be stored at 4~30℃ in a sealed aluminum foil bag. Take the product within 1 month of the expiration date for testing, and the test results should meet the requirements of items 2.1~2.7. |
IL-6 (Interleukin-6)
Target Introduction:
IL-6 (Interleukin-6) is a pleiotropic cytokine that plays a crucial role in the immune system and other biological systems. It participates in various physiological events in different organs, including inflammation, hematopoiesis, and oncogenesis. IL-6 regulates cell growth, gene activation, proliferation, survival, and differentiation.
IL-6 signals through a receptor complex composed of two subunits: an alpha subunit (responsible for ligand specificity) and GP130 (Glycoprotein 130), a receptor subunit shared by other cytokines in the IL-6 family. Binding of IL-6 to its receptor initiates cellular events such as:
- Activation of JAK (Janus Kinase) kinases
- Activation of Ras-mediated signaling.
Activated JAK kinases phosphorylate and activate STAT transcription factors, particularly STAT3 (Signal Transducers and Activators of Transcription-3) and SHP2 [SH2 (Src Homology-2) Domain-containing Tyrosine Phosphatase]. Phosphorylated STAT3 dimerizes, translocates to the nucleus, and activates transcription of genes containing STAT3 response elements. STAT3 is crucial for GP130-mediated cell survival and G1 to S cell-cycle-transition signals. c-Myc and Pim are identified as STAT3 target genes, compensating for STAT3 in cell survival and cell-cycle transition. SHP2 links the cytokine receptor to the Ras/MAP (Mitogen-Activated Protein) kinase pathway and is essential for mitogenic activity.
Applications in IVD:
IL-6 is used as a target in In Vitro Diagnostics (IVD). Reportedly, it can be used in LF (Lateral Flow Assay) and FIA (Fluorescence Immunoassay).
Technology Transfer
Technology transfer and customization
For research institutions and growing enterprises, especially those in the early stages of development, we offer a comprehensive suite of mature and stable production process technology transfer, along with relevant process documentation.
Additionally, we can tailor transformation production processes to align with diverse customer requirements and market needs.
This approach not only expedites the R&D and production process optimization timeline but also significantly reduces time and capital investment for our clients.
Expert lectures
The course will be led by seasoned industry experts, covering a range of topics including immunochromatography knowledge, theoretical explanations of process flows, and hands-on experimental operations. It will systematically address and analyze technical challenges faced by customers in their R&D and production processes, offering practical solutions.
Additionally, the course will feature demonstrations and practical operation sessions focused on immunochromatography equipment that is of particular interest to participants.
Process
The process unfolds as follows:
The customer outlines their requirements -> we collaborate to explore feasible solutions -> the customer settles the fee -> based on the provided solution, the customer either attends on-site training or receives remote guidance -> should production issues arise, we dispatch experts to the customer's site to offer on-site guidance and resolve the problems.
Research Outsourcing
We provide a variety of scientific and technical services, including laboratory equipment, experimental materials, data analysis and report writing, etc.
- Experimental Consumables and Chemical Reagents: We provide a comprehensive range of consumables and chemical reagents required for various experiments to meet the diverse needs of scientific research.
- Data Analysis: We are responsible for collecting and conducting in-depth analysis of experimental data, generating detailed reports to lay a solid foundation for the presentation of research findings.
- Technical Support: We offer comprehensive technical support to ensure the smooth progress of experiments, facilitating the successful conduct of research work.
- Customized Services: We possess the capability to tailor scientific and technological services to meet the specific needs and expectations of our clients, ensuring a high level of alignment and effectiveness in our offerings.
- One-Stop Services: We provide comprehensive one-stop scientific research services, including equipment rental and experimental material procurement, aiming to deliver a convenient and efficient user experience while streamlining the research process.
Process:
- Customer Submits Requirements: The customer clearly outlines their research or production needs, laying the foundation for subsequent services.
- Exploring Feasible Solutions: We engage in in-depth communication with the customer to jointly explore and formulate practical solutions, ensuring the forward-looking and operational nature of the service.
- Customer Pays Fees: Upon reaching a mutual agreement, the customer settles the relevant fees, providing assurance for the formal initiation of the service.
- Conducting Experiments or Data Characterization Analysis for the Customer: Based on the agreed-upon plan, we perform experimental operations or data characterization analysis for the customer, ensuring the process is professional and precise.
- Providing the Customer with a Detailed Experimental Report: Upon completion of the experiments or analysis, we deliver a comprehensive experimental report to the customer, offering robust support for their research or production decisions.
Semi-finished Products (large Packaging)
We can provide semi-finished (bulk packaged) reagents for quick assembly and application in your own country.
Advantages of Semi-Finished Reagents for Local Assembly:
- Rapid Market Entry: Quick assembly allows for swift deployment and faster market penetration.
- Compliance: Meets government self-production mandates and local regulatory requirements.
- Cost Efficiency: Reduces logistics and capital investment costs.
- Scalability: Flexible production adapts to market demand.
- Quality Assurance: Ensures consistent quality with local oversight.
- Competitive Edge: Combines global expertise with local production for a strategic advantage.
PDF - Interleukin-6 (IL-6)
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