Anti-RNASE6 Polyclonal Antibody for WB, IF, IHC, ELISA - Q93091

Core Product Specifications and Parameters

Biological Background: RNASE6 Function and Localization

• RNASE6, also known as RAD1, RNS6, RNasek6, is a secreted ribonuclease (RNase K6).
• It preferentially hydrolyzes pyrimidine nucleotides uridine and cytosine. Related references: PMID:27013146, PMID:8836175
• RNASE6 demonstrates potent antibacterial activity against both Gram-positive and Gram-negative bacteria, including clinically relevant strains. Related references: PMID:25075772, PMID:27089320
• Its bactericidal mechanism involves disruption of bacterial membrane integrity and agglutination of Gram-negative bacteria. Related references: PMID:27089320
• The antibacterial effect is independent of its ribonucleolytic activity. Related references: PMID:27089320
• RNASE6 likely contributes to maintaining urinary tract sterility. Related references: PMID:25075772
• Subcellularly, RNASE6 is found in lysosomes, cytoplasmic granules, and is secreted.
• It is highly expressed in spleen, lung, and thymus; present in monocytes and neutrophils; absent in healthy kidney but detected in infected kidney interstitial leukocytes.

Experimental Guidance and Technical Tips

• For Western blotting, consider a primary antibody dilution optimized for your sample and detection system; the predicted molecular weight is ~17 kDa.
• In immunohistochemistry or immunofluorescence, validate the antibody in relevant tissue types based on the known expression pattern (e.g., spleen, lung, infected kidney).
• As a polyclonal antibody, it may recognize multiple epitopes; confirm specificity in your context using appropriate controls.

CamelBio: Your One-Stop Sourcing Bridge

• CamelBio is a one-stop partner providing IVD raw materials, technical services, and consulting. Complement your RNASE6 research with validated antibody pairs, recombinant proteins, and ancillary reagents for urinary tract infection or antimicrobial studies. Our team supports rare target sourcing and bulk supply to accelerate your diagnostic development.