Anti-Dengue virus (NS1) dengue clia / elisa rapid test

Product Overview Table

Storage and Transportation Conditions Table

Finished Product Performance Indicator Table

Anti-Dengue virus (NS1)

Target Introduction:

Dengue virus (DENV) is a mosquito-borne virus belonging to the Flaviviridae family. Its RNA genome encodes three structural and seven nonstructural (NS) proteins. Nonstructural protein 1 (NS1) is a multifunctional protein actively secreted by both vertebrate and mosquito cells during infection. In mosquito cells, NS1 secretion occurs unconventionally, dependent on caveolin-1.

Secretion Mechanism in Mosquito Cells:

NS1 associates with and relies on the caveolin chaperone complex (CCC) for secretion in mosquito cells. The CCC comprises caveolin-1 and the chaperones FKBP52, Cy40, and CyA, responsible for cholesterol trafficking inside the cell. Classic secretion inhibitors (e.g., brefeldin A, Golgicide A, and Fli-06) don't significantly impact NS1 secretion but significantly reduce recombinant luciferase secretion and virion release in mosquito cells. Silencing CAV-1 or FKBP52, or inhibiting CyA, decreases NS1 secretion without affecting virion release. NS1 colocalizes and interacts with all CCC proteins, and CAV-1 and FKBP52 expression is augmented in DENV-infected cells. Zika virus (ZIKV) NS1 follows the same secretory pathway as DENV NS1 in mosquito cells.

Application:

• Lateral Flow Assay (LF)
• ELISA
• Immunofluorescence Assay (IFA)

Technology Transfer

Technology transfer and customization

For research institutions and growing enterprises, especially those in the early stages of development, we offer a comprehensive suite of mature and stable production process technology transfer, along with relevant process documentation. 

Additionally, we can tailor transformation production processes to align with diverse customer requirements and market needs. 

This approach not only expedites the R&D and production process optimization timeline but also significantly reduces time and capital investment for our clients.

Expert lectures

The course will be led by seasoned industry experts, covering a range of topics including immunochromatography knowledge, theoretical explanations of process flows, and hands-on experimental operations. It will systematically address and analyze technical challenges faced by customers in their R&D and production processes, offering practical solutions. 

Additionally, the course will feature demonstrations and practical operation sessions focused on immunochromatography equipment that is of particular interest to participants.

Process

The process unfolds as follows: 

The customer outlines their requirements -> we collaborate to explore feasible solutions -> the customer settles the fee -> based on the provided solution, the customer either attends on-site training or receives remote guidance -> should production issues arise, we dispatch experts to the customer's site to offer on-site guidance and resolve the problems.

Research Outsourcing

We provide a variety of scientific and technical services, including laboratory equipment, experimental materials, data analysis and report writing, etc.

• ‌Experimental Consumables and Chemical Reagents: We provide a comprehensive range of consumables and chemical reagents required for various experiments to meet the diverse needs of scientific research.
• ‌Data Analysis: We are responsible for collecting and conducting in-depth analysis of experimental data, generating detailed reports to lay a solid foundation for the presentation of research findings.
• ‌Technical Support: We offer comprehensive technical support to ensure the smooth progress of experiments, facilitating the successful conduct of research work.
• ‌Customized Services: We possess the capability to tailor scientific and technological services to meet the specific needs and expectations of our clients, ensuring a high level of alignment and effectiveness in our offerings.
• ‌One-Stop Services: We provide comprehensive one-stop scientific research services, including equipment rental and experimental material procurement, aiming to deliver a convenient and efficient user experience while streamlining the research process.

Process:

• Customer Submits Requirements: The customer clearly outlines their research or production needs, laying the foundation for subsequent services.
• Exploring Feasible Solutions: We engage in in-depth communication with the customer to jointly explore and formulate practical solutions, ensuring the forward-looking and operational nature of the service.
• Customer Pays Fees: Upon reaching a mutual agreement, the customer settles the relevant fees, providing assurance for the formal initiation of the service.
• Conducting Experiments or Data Characterization Analysis for the Customer: Based on the agreed-upon plan, we perform experimental operations or data characterization analysis for the customer, ensuring the process is professional and precise.
• Providing the Customer with a Detailed Experimental Report: Upon completion of the experiments or analysis, we deliver a comprehensive experimental report to the customer, offering robust support for their research or production decisions.

Semi-finished Products (large Packaging)

We can provide semi-finished (bulk packaged) reagents for quick assembly and application in your own country.

Advantages of Semi-Finished Reagents for Local Assembly:

• Rapid Market Entry: Quick assembly allows for swift deployment and faster market penetration.
• Compliance: Meets government self-production mandates and local regulatory requirements.
• Cost Efficiency: Reduces logistics and capital investment costs.
• Scalability: Flexible production adapts to market demand.
• Quality Assurance: Ensures consistent quality with local oversight.
• Competitive Edge: Combines global expertise with local production for a strategic advantage.