YWHAZ/14-3-3 zeta/delta Rabbit pAb for WB, ELISA - P63104

Core Product Specifications and Parameters

Biological Background: 14-3-3 zeta/delta (YWHAZ) Function and Localization

• Also known as protein kinase C inhibitor protein 1 (KCIP-1), this adapter protein is central to a broad spectrum of signaling pathways. Related references: PMID:14578935, PMID:15071501, PMID:15644438
• Binds to numerous partners, typically via phosphoserine or phosphothreonine motifs, thereby modulating their activity. Related references: PMID:35662396
• Induces ARHGEF7 activity on RAC1, promoting lamellipodia and membrane ruffle formation. Related references: PMID:16959763
• Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB. Related references: PMID:35662396
• In neurons, contributes to spine maturation through modulation of ARHGEF7 activity.
• Localizes primarily to the cytoplasm and melanosomes.
• Undergoes alternative splicing and post-translational modifications including phosphorylation and acetylation.
• Genetic variants are associated with intellectual disability; the protein also interacts with viral factors.

Experimental Guidance and Technical Tips

• The immunogen covers a central region (aa 146–245) of human YWHAZ, which may help recognize both native and denatured forms; consider this when planning assays.
• Suitable for Western blot (WB) and ELISA; optimize dilution factors for each application using the relevant sample system.
• Predicted to cross-react with mouse and rat YWHAZ based on sequence similarity; confirm specificity in your experimental model.
• As a signaling adapter, YWHAZ abundance may vary with cell cycle or stimulation; control for these variables in quantitative experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with reliable access to critical IVD raw materials like this anti-YWHAZ polyclonal antibody, which supports studies of phosphorylation-dependent signaling. Beyond single-antibody sourcing, we facilitate procurement of validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare-target raw materials — helping you bridge from discovery to diagnostic development efficiently.