YEATS2 Rabbit Polyclonal Antibody for WB, ELISA - Q9ULM3

Core Product Specifications and Parameters

Biological Background: YEATS2 Function and Localization

• YEATS2 (FAME4) is a chromatin reader component of the ATAC complex, which possesses histone acetyltransferase activity on histones H3 and H4. Related references: PMID:18838386 PMID:19103755 PMID:27103431
• YEATS2 specifically recognizes and binds histone H3 crotonylated at Lys-27 (H3K27cr). Related references: PMID:27103431
• H3K27 crotonylation marks active promoters and enhancers, conferring resistance to transcriptional repressors. Related references: PMID:27103431
• YEATS2 localizes to the nucleus.
• Post-translational modifications: YEATS2 is a phosphoprotein and can be modified by ubiquitination (isopeptide bond).
• UniProt annotations include a coiled-coil domain, 3D-structure determination, and potential involvement in epilepsy.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 130–331) is likely surface-exposed, promoting efficient antibody generation for WB and ELISA.
• Predicted molecular weight of ~151 kDa: use low-percentage SDS-PAGE and appropriate transfer conditions for high-molecular-weight proteins.
• Cross-reactivity with mouse and rat indicates conserved epitopes; always validate specificity in your target sample system.
• For ELISA, test recombinant or native protein to determine optimal coating and detection parameters.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a complete suite of IVD raw materials, including validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents for epigenetics and chromatin research. As a dedicated procurement partner, we simplify access to rare-target antibodies like anti-YEATS2, supporting diagnostic manufacturers and laboratories from early-stage development to clinical application. Contact us to explore custom sourcing and technical support offerings.