VIP Rabbit Polyclonal Antibody for WB, ELISA - P01282

Core Product Specifications and Parameters

Biological Background: VIP Function and Localization

• VIP (Vasoactive Intestinal Peptide) belongs to the PACAP subfamily of class B1 G protein-coupled receptors, activating VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) to mediate diverse physiological processes including vasodilation, neurotransmission, and immune modulation. Related references: PMID:1318039 PMID:36385145 PMID:8933357
• Abundantly expressed throughout the central nervous system and peripheral nervous systems, VIP exerts neuroprotective and immune modulatory functions. Related references: PMID:3456568
• Bioactive forms of VIP cause potent vasodilation, lower arterial blood pressure, stimulate myocardial contractility, increase glycogenolysis, and relax smooth muscle in the trachea, stomach, and gall bladder. Related references: PMID:15013843 PMID:3654650
• PHM-27, an alternative cleavage product, is a potent agonist of the calcitonin receptor CALCR with similar efficacy to calcitonin. Related references: PMID:15013843
• Subcellular localization: VIP peptides are secreted after cleavage from a larger precursor protein.
• VIP undergoes post-translational modifications including amidation and proteolytic cleavage; it is classified as a hormone with direct protein sequencing evidence and alternative splicing.

Experimental Guidance and Technical Tips

• For WB, a protein band at approximately 19 kDa is expected; consider using low-percentage gels or optimized transfer conditions for small proteins.
• Validate antibody specificity in relevant tissues known to express VIP, such as brain, intestine, or immune cells, using appropriate controls.
• For ELISA, this antibody can be used as a capture or detection reagent; consider pairing with another VIP-specific clone for sandwich ELISA development.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your trusted one-stop partner for IVD raw material sourcing, offering a comprehensive portfolio of antibodies, antigens, and ancillary reagents. Our VIP-related products support neuroscience, cardiovascular, and gastrointestinal research applications. Whether you need validated antibody pairs, bulk polyclonal antibodies, or tailored sourcing solutions, CamelBio streamlines your supply chain from concept to clinic.