UGT2B7 Rabbit pAb - P16662

Core Product Specifications and Parameters

Biological Background: UGT2B7 Function and Localization

• UGT2B7, also known as UDP-glucuronosyltransferase 2B9 or UDPGTh-2, is a key phase II metabolizing enzyme that conjugates glucuronic acid to lipophilic substrates, enhancing their water solubility for excretion into urine or bile. Related references: PMID:10702251, PMID:15231852, PMID:15470161
• Essential for the detoxification and elimination of drugs, xenobiotics, and endogenous compounds. Related references: PMID:15470161, PMID:18674515, PMID:23756265
• Catalyzes the glucuronidation of steroid hormones including androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Related references: PMID:15472229, PMID:17442341, PMID:18719240
• Regulates levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Related references: PMID:10702251
• Contributes to bile acid detoxification through glucuronidation, supporting dietary lipid absorption. Related references: PMID:23756265
• Involved in the glucuronidation of arachidonic acid and eicosanoids (e.g., 15-HETE, 20-HETE, PGE2) and the phytochemical ferulic acid. Related references: PMID:15231852, PMID:38211441, PMID:21422672
• Metabolizes therapeutic agents such as losartan, candesartan, zolarsartan, and the immunosuppressive drug mycophenolate. Related references: PMID:18674515, PMID:15470161
• Localizes to the endoplasmic reticulum membrane, a transmembrane glycoprotein with a signal peptide.

Experimental Guidance and Technical Tips

• The immunogen (residues 25–351) covers a large portion of the luminal domain, so the antibody is suitable for detecting native and denatured UGT2B7 in WB and IF/ICC.
• For WB, expect a band around 61 kDa under reducing conditions; additional bands may appear due to glycosylation or homologous isoforms.
• Given cross-reactivity with mouse and rat, consider sequence alignment to assess isoform specificity; human UGT2B family members share high homology, so cross-reactivity with UGT2B4, UGT2B15, etc., is possible.
• For ELISA, optimize coating conditions and antibody dilutions; pairing with a capture antibody may improve assay performance.
• Validate all applications in the relevant sample matrix to confirm specificity, especially if studying drug metabolism pathways.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop partner for IVD raw materials, offering validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. This UGT2B7 antibody supports research in drug metabolism, hormone conjugation, and xenobiotic detoxification—critical areas for diagnostic development. Whether you need rare target sourcing or technical consulting, CamelBio streamlines your path from concept to clinic.