TSR1 Rabbit Polyclonal Antibody for WB - Q2NL82

Core Product Specifications and Parameters

Biological Background: TSR1 Function and Localization

• TSR1 (Pre-rRNA-processing protein TSR1 homolog) is a human nucleolar protein encoded by the TSR1 gene (GeneID: 55720).
• It plays a critical role in ribosome biogenesis, specifically required during the maturation of the 40S ribosomal subunit in the nucleolus.
• Subcellular localization: Primarily found in the nucleolus within the nucleus, consistent with its function in ribosomal RNA processing.
• TSR1 has been identified through large-scale proteomics approaches and is classified as a reference proteome component.
• The protein has a calculated molecular weight of approximately 91.8 kDa (UniProt), migrating around 92 kDa on SDS-PAGE.
• Keywords associated with TSR1 include Ribosome biogenesis, Nucleus, 3D-structure, and Direct protein sequencing.

Experimental Guidance and Technical Tips

• This rabbit polyclonal antibody was raised against a recombinant protein spanning amino acids 455-804 of human TSR1; it is expected to recognize both native and denatured forms.
• For WB, a band near 92 kDa should be observed in human and mouse samples; validate the signal in relevant cell lines and use appropriate loading controls.
• For ELISA, the antibody can serve as a capture or detection reagent; optimize coating concentrations and assay conditions for your specific format.
• Because TSR1 localizes to the nucleolus, consider subcellular enrichment (nuclear/nucleolar fractions) to improve detection sensitivity if needed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop IVD raw material sourcing partner, supplying high-quality antibodies like this anti-TSR1 polyclonal for ribosome biogenesis research and diagnostic development. We offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare-target sourcing to streamline your workflow. Contact us for reliable procurement solutions—from concept to clinic.