TMX2 Rabbit Polyclonal Antibody for WB, IHC-P, IF/ICC, ELISA - Q9Y320

Core Product Specifications and Parameters

Biological Background: TMX2 Function and Localization

• TMX2 is a thioredoxin-related transmembrane protein also known as cell proliferation-inducing gene 26 protein (PIG26) and thioredoxin domain-containing protein 14 (TXNDC14).
• It functions as a regulator of cellular redox state, influencing protein post-translational modification, protein folding, and mitochondrial activity.
• TMX2 localizes to both the endoplasmic reticulum and mitochondrial membranes and is widely expressed across tissues.
• The protein may play a role in neuronal proliferation, migration, and organization during brain development.
• TMX2 contains a predicted signal peptide, a transmembrane helix, and a thioredoxin domain; it undergoes disulfide bond formation and phosphorylation.
• Consistent with its neuronal role, disease variants of TMX2 have been associated with intellectual disability and lissencephaly.

Experimental Guidance and Technical Tips

• The immunogen targets amino acids 128-296 of human TMX2 (NP_057043.1); this mid-region sequence may recognize multiple isoforms—validate in the relevant sample system.
• For Western blot (WB), the predicted molecular weight is 34 kDa; consider using reducing conditions and appropriate loading controls.
• For IHC-P and IF/ICC, optimize antigen retrieval and permeabilization protocols due to the transmembrane localization of TMX2.
• ELISA applications can be developed using this antibody for detection in cell lysates or recombinant protein samples; consider an indirect ELISA format.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a one-stop sourcing partner for IVD raw materials, offering high-quality antibodies such as this TMX2 polyclonal antibody for research into cellular redox regulation and ER-mitochondrial biology. We provide tailored supply solutions including validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and custom sourcing of rare targets to accelerate your development pipeline.