TAF6L Rabbit Polyclonal Antibody for WB, IP, ELISA - Q9Y6J9

Core Product Specifications and Parameters

Biological Background: TAF6L Function and Localization

• TAF6L, also known as PAF65-alpha, is a component of the PCAF complex, which possesses histone acetyltransferase activity capable of acetylating histones in a nucleosomal context.
• Functions as a component of the human version of the yeast SAGA complex, linking histone acetylation to transcriptional regulation.
• Along with TAF5L, acts as an epigenetic regulator essential for somatic reprogramming; regulates target genes through H3K9ac deposition and MYC recruitment, thereby controlling embryonic stem cell state.
• Functions together with MYC to activate target gene expression via RNA polymerase II pause release.
• Localizes to the nucleus, consistent with its role in transcriptional regulation.
• Post-translationally modified by methylation and phosphorylation, as identified in proteomic studies; also has a known 3D-structure.

Experimental Guidance and Technical Tips

• The immunogen spans the N-terminal region (aa 1-200) of human TAF6L, which is likely conserved across species—supporting the observed cross-reactivity with mouse and rat.
• For Western blot, the predicted molecular weight is ~68 kDa; consider using appropriate loading controls and validating in your specific model system.
• IP and ELISA applications are suggested; empirical optimization of antibody concentration and buffer conditions is recommended.
• As a polyclonal antibody, batch-to-batch consistency should be verified for critical quantitative assays.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated one-stop supplier of IVD raw materials, streamlining the path from concept to clinic. This anti-TAF6L polyclonal antibody is part of our portfolio supporting transcriptional regulation and epigenetics research. Beyond individual antibodies, we offer validated antibody pairs, optimized monoclonal and polyclonal reagents, bulk ancillary supplies, and sourcing of rare targets to meet diverse diagnostic development needs.