SUZ12 Rabbit Monoclonal Antibody for WB, ELISA - Q15022

Core Product Specifications and Parameters

Biological Background: SUZ12 Function and Localization

• SUZ12 is a Polycomb group (PcG) protein and a core component of the PRC2 complex, responsible for methylating histone H3 at Lys-9 (H3K9me) and Lys-27 (H3K27me) to mediate transcriptional repression. Related references: PMID:15225548 PMID:15231737 PMID:15385962

• The PRC2 complex recruits DNA methyltransferases, linking histone methylation and DNA methylation in epigenetic silencing. Related references: PMID:12351676 PMID:12435631 PMID:15099518

• PRC2 target genes include HOXC8, HOXA9, MYT1 and CDKN2A, which are repressed to regulate developmental and tumor suppressor pathways. Related references: PMID:15231737 PMID:16618801 PMID:17200670

• SUZ12 localizes to the nucleus, consistent with its role in chromatin modification and gene regulation.

• Overexpression of SUZ12 is observed in breast and colon cancer, implicating it in oncogenesis.

• SUZ12 contains a zinc-finger domain, is subject to phosphorylation and ubiquitination, and is involved in chromosomal rearrangements associated with disease.

• Alternative names include Chromatin precipitated E2F target 9 protein (ChET 9) and Joined to JAZF1 protein, reflecting its association with fusion proteins.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1-96) of human SUZ12, which may target epitopes conserved across human, mouse, and rat.
• For Western blotting, consider using nuclear extracts to enrich SUZ12 signal, and validate the observed band near 83 kDa.
• Optimize antibody dilution and incubation conditions for your specific ELISA or WB protocol, and include appropriate controls to confirm specificity.

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CamelBio is your trusted partner for IVD raw-material sourcing, providing a comprehensive portfolio from monoclonal antibodies to ancillary reagents. This SUZ12 antibody supports epigenetic and oncology research, and CamelBio ensures reliable access to validated antibodies and bulk supplies for diagnostic assay development. We help you accelerate from concept to clinic with tailored sourcing solutions.