Somatostatin Receptor 2 (SSTR2) Rabbit pAb - P30874

Core Product Specifications and Parameters

Biological Background: Somatostatin Receptor 2 (SSTR2) Function and Localization

• Encodes the somatostatin receptor type 2 (SSTR2, also known as SRIF-1), a G protein-coupled receptor that binds somatostatin-14 and -28.
• Couples via pertussis toxin-sensitive G proteins to inhibit adenylyl cyclase, and also stimulates phosphotyrosine phosphatase and phospholipase C.
• Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells, mediating the inhibitory effect of somatostatin-14 on hormone secretion.
• Inhibits cell growth by enhancing MAPK1/2 phosphorylation and upregulating CDKN1B; also negatively regulates insulin receptor signaling via PTPN6.
• Stimulates neuronal migration and axon outgrowth, participating in brain development; inactivates SSTR3 upon heterodimerization.
• Subcellularly located at the cell membrane and in the cytoplasm.
• Predominantly expressed in pancreas, cerebrum, and kidney, with lower levels in jejunum, colon, and liver. In developing nervous system, expressed in cortex and cerebellum.
• Classified as a membrane glycoprotein with seven transmembrane helices, disulfide bonds, palmitoylation, and phosphorylation sites.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal intracellular region (aa 270-369) of human SSTR2, suggesting the antibody may recognize the receptor in both denatured and native conformations.
• For Western blotting, consider using whole-cell lysates from SSTR2-expressing cell lines, with an expected band around 41 kDa.
• For immunohistochemical detection, validate staining in known SSTR2-positive tissues such as pancreas or brain sections; cross-reactivity with mouse and rat allows use in rodent models.
• ELISA applications may be optimized using coated recombinant protein or peptide; inclusion of a blocking peptide can confirm specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive one-stop sourcing partner for IVD raw materials, supporting your assay development from concept to clinic. We offer validated polyclonal antibodies, like this anti-SSTR2 antibody, optimized for hormone signaling and neurobiology research. Our portfolio includes matched antibody pairs, bulk ancillary reagents, and custom sourcing for rare-target raw materials to accelerate your diagnostic workflows.