SNAI3 Rabbit Polyclonal Antibody for WB and ELISA - Q3KNW1

Core Product Specifications and Parameters

Biological Background: SNAI3 Function and Localization

• SNAI3, also known as SMUC, SNAIL3, ZNF293, or Zfp293, is a zinc finger protein belonging to the Snail family of transcriptional repressors.
• It functions as a transcriptional repressor by binding to canonical E-box sequences (5'-CAGGTG-3' and 5'-CACCTG-3') to inhibit E-box-dependent transactivation of downstream myogenic bHLH genes, thereby suppressing myoblast differentiation (By similarity).
• The protein localizes to the nucleus, consistent with its role in transcription regulation.
• SNAI3 contains zinc-finger repeats, which mediate DNA binding, and is involved in metal binding and transcription regulation.
• As a member of the Snail family, it may share structural and functional similarities with other family members, though specific tissue expression patterns are not fully characterized.

Experimental Guidance and Technical Tips

• Since this is a polyclonal antibody, it may recognize multiple epitopes, potentially increasing sensitivity but also the chance of cross-reactivity; validate in relevant sample systems.
• For Western blotting, the predicted molecular weight is 32 kDa; confirm band specificity using positive and negative controls.
• The immunogen corresponds to amino acids 7-186, covering nearly the full-length protein, suggesting recognition of multiple isoforms if any; consider verifying with isoform-specific controls.
• For ELISA, optimize coating antigen and antibody dilution to achieve the best signal-to-noise ratio.
• This antibody is reported to cross-react with human, mouse, and rat; however, always verify cross-reactivity in your specific experimental setup.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop source for IVD raw materials, offering validated antibody pairs, monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target sourcing. This SNAI3 antibody supports research in transcriptional regulation and developmental biology. Partner with CamelBio to streamline your diagnostic development from concept to clinic.