SMNDC1 Rabbit Polyclonal Antibody for WB, ELISA - O75940

Core Product Specifications and Parameters

Biological Background: SMNDC1 Function and Localization

• SMNDC1, also known as survival of motor neuron-related-splicing factor 30, SPF30, or SMNR, is encoded by the SMNDC1 gene (GeneID: 10285) and is a member of the survival motor neuron domain-containing protein family.
• The protein functions as a component of the spliceosome, playing a role in pre-mRNA splicing.
• It localizes predominantly to nuclear speckles and Cajal bodies within the nucleus, consistent with its involvement in mRNA processing.
• Post-translational modifications include acetylation and phosphorylation, which may regulate its activity in spliceosome dynamics and apoptosis.
• Tissue expression is notable in skeletal muscle at intermediate levels, with lower expression detected in heart and pancreas.
• Keywords associated with SMNDC1 include mRNA processing, mRNA splicing, spliceosome, and apoptosis, reflecting its critical roles in gene expression regulation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the full-length N-terminal region (aa 1-238) of human SMNDC1, suggesting the antibody may recognize both full-length and truncated forms; validate in the relevant sample system.
• For Western blotting, consider a starting dilution based on standard rabbit polyclonal protocols and optimize using appropriate positive controls such as HeLa or HEK293 cell lysates (expressing SMNDC1 at moderate levels).
• In ELISA, direct detection of recombinant or purified native SMNDC1 may be feasible; perform serial dilutions to determine optimal working range.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This SMNDC1 antibody is part of our comprehensive portfolio supporting splicing and mRNA processing research. We offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to accelerate your diagnostic development.