SBDS Rabbit pAb for WB, ELISA - Q9Y3A5

Core Product Specifications and Parameters

Biological Background: SBDS Function and Localization

• SBDS (Shwachman-Bodian-Diamond syndrome protein) is a ribosomal maturation factor essential for ribosome biogenesis and translation.
• Together with EFL1, SBDS triggers GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, enabling 80S ribosome assembly and recycling EIF6 to the nucleus for 60S rRNA processing and nuclear export.
• It is required for normal levels of protein synthesis and has been implicated in cellular stress resistance, DNA damage response, and cell proliferation.
• SBDS is widely expressed across tissues and localizes to the cytoplasm, nucleolus, nucleoplasm, and spindle.
• Post-translational modifications include acetylation; SBDS is a reference proteome member and is associated with the ribosome biogenesis keyword.
• Mutations in SBDS are linked to Shwachman-Diamond syndrome, a congenital bone marrow failure disorder.
• The protein has a known 3D structure and has been identified through direct protein sequencing and proteomics.

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal region (aa 1–250) of human SBDS, which may recognize both full-length and truncated forms of the protein.
• For Western blotting, a specific band around 29 kDa (predicted molecular weight) is expected; consider using positive controls such as HeLa or HEK293 cell lysates and validate in your sample system.
• Due to cross-reactivity with mouse and rat, this antibody can be used in rodent models; however, confirm reactivity and optimal dilution in your experimental setup.
• In ELISA applications, the antibody may serve as a capture or detection reagent; perform pairing and titer optimization as part of assay development.
• Store the antibody as recommended and avoid repeated freeze-thaw cycles to maintain performance.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers, laboratories, and research institutes a streamlined, one-stop sourcing solution for IVD raw materials, technical services, and consulting—from early concept through clinical application. This high-quality anti-SBDS rabbit polyclonal antibody supports studies in ribosome biogenesis, protein translation, and Shwachman-Diamond syndrome. Leverage our broad portfolio, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target sourcing, to accelerate your assay development with reliable supply and expert support.