RBMY1A1 Rabbit pAb - P0DJD3

Core Product Specifications and Parameters

Biological Background: RBMY1A1 Function and Localization

• RBMY1A1, also known as RBM1, RBM2, YRRM1, or hRBMY, is a member of the RNA-binding motif protein family encoded by the Y chromosome gene RBMY1A1.
• It functions as an RNA-binding protein that is specifically involved in pre-mRNA splicing regulation.
• RBMY1A1 is essential for sperm development, acting additively with TRA2B to promote inclusion of exon 7 in the survival motor neuron (SMN) mRNA.
• The protein binds non-specifically to mRNAs and is classified under alternative splicing and mRNA processing pathways.
• RBMY1A1 localizes exclusively to the nucleus, consistent with its role in mRNA splicing.
• Tissue expression is highly restricted to the testis, aligning with its critical function in spermatogenesis.
• Keywords also highlight its activator role and the availability of a 3D structure for reference.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 90-300, a region that may contain the RNA recognition motif (RRM); consider epitope mapping if specific domain binding is required.
• For immunofluorescence (IF-P) and immunohistochemistry (IHC-P), nuclear staining is expected; validate in human, mouse, or rat testis tissue sections.
• Cross-reactivity with mouse and rat is indicated; perform species-specific validation to confirm reactivity in your sample system.
• ELISA applications can be considered using the recombinant protein as a standard; optimize coating and detection conditions empirically.

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• CamelBio serves as a comprehensive sourcing partner for IVD raw materials, offering validated antibody pairs, optimized polyclonal and monoclonal antibodies, and bulk ancillary reagents for reproductive biology and RNA processing research.
• Whether you need ready-to-use anti-RBMY1A1 antibodies or custom sourcing for rare targets, our one-stop platform bridges the gap from concept to clinic efficiently.