Rabbit anti-RALB Polyclonal Antibody for WB, IHC-P, ELISA - P11234

Core Product Specifications and Parameters

Biological Background: RALB Function and Localization

• RALB encodes Ras-related protein Ral-B, a member of the Ras small GTPase superfamily.
• It functions as a multifunctional GTPase involved in diverse processes: gene expression, cell migration, cell proliferation, oncogenic transformation, and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269). Related references: PMID:10393179 PMID:17875936 PMID:18756269
• RALB acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles and stabilizes exocyst complex assembly at the leading edge of migrating cells (by similarity).
• Plays a critical role in apoptosis suppression (PubMed:17875936). Related references: PMID:17875936
• In late cytokinesis, it mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). Related references: PMID:18756269
• Involved in ligand-dependent endocytosis of EGF and insulin receptors (PubMed:10393179). Related references: PMID:10393179
• The protein undergoes alternative splicing, prenylation, and methylation, and is localized to the cell membrane and midbody.
• Key biological keywords include GTP-binding, hydrolase, membrane, apoptosis, cell cycle/division, and oncogene.

Experimental Guidance and Technical Tips

• The immunogen covers the full-length human RALB protein (aa 1-206), likely generating antibodies that recognize multiple epitopes. Consider this broad recognition for applications such as WB, IHC-P, and ELISA.
• For WB, the predicted molecular weight is approximately 23 kDa; validate band detection in the relevant sample system.
• IHC-P may require optimization of antigen retrieval methods for optimal signal.
• ELISA can be used for quantitative detection; consider pairing with a suitable detection antibody.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This product targets the Ras-related GTPase RALB, relevant for oncology and cell biology research. We offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to support your IVD development.