Rabbit anti-Mouse CX3CR1 Monoclonal Antibody for FC - Q9Z0D9

Core Product Specifications and Parameters

Biological Background: CX3CR1 Function and Localization

• CX3CR1 is the receptor for the CX3C chemokine fractalkine (CX3CL1), mediating immune response, inflammation, cell adhesion, and chemotaxis.
  Related references: PMID:10187784, PMID:9918795
• It plays a key role in leukocyte migration, including recruitment of NK cells to inflamed tissues and monocyte/macrophage recruitment in atherosclerosis.
  Related references: PMID:11544273, PMID:12871640, PMID:16675847, PMID:12569158, PMID:18971423
• In the central nervous system, CX3CR1 is critical for microglial function, regulating inflammatory responses and synaptic pruning during brain development.
  Related references: PMID:16732273, PMID:21778362, PMID:24487234
• CX3CR1 is involved in gut immunity, controlling responses to intestinal bacteria and fungi.
  Related references: PMID:15653504, PMID:29326275, PMID:33548172
• The protein is expressed on subsets of leukocytes, including monocytes, NK cells, T cells, dendritic cells, and microglia, with expression levels distinguishing monocyte subsets.
  Related references: PMID:10805752, PMID:12871640, PMID:16732273, PMID:15653504
• CX3CR1 localizes to the cell membrane and is a G protein-coupled receptor with seven-transmembrane domains.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide mapping to the N-terminal extracellular region (amino acids 1-100) of mouse CX3CR1. This design may be suitable for detecting surface-expressed receptor in live-cell flow cytometry assays.
• Since the antibody is directly conjugated with , it is ready-to-use in flow cytometry protocols. Consider titrating the antibody to determine the optimal concentration for your specific cell type.
• Include appropriate controls: an isotype control conjugated with the same fluorophore, and a fluorescence-minus-one (FMO) control if using multicolor panels.
• This product is reported to react with mouse CX3CR1. Validate cross-reactivity in your experimental system if using cells from other species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-CX3CR1 antibody supports studies in immunology, neuroscience, and gut microbiota, and is part of our broader portfolio of validated monoclonal antibodies and ancillary reagents. For rare target sourcing, bulk orders, or customized IVD solutions, CamelBio serves as your trusted procurement partner.