ABflo 647 Rabbit anti-Mouse CD267/TACI Monoclonal Antibody for Flow Cytometry - Q9ET35

Core Product Specifications and Parameters

Biological Background: CD267/TACI Function and Localization

• CD267, also known as TACI (Transmembrane activator and CAML interactor), is a tumor necrosis factor receptor superfamily member 13B (Tnfrsf13b), encoded by the Taci gene in mouse.
• It functions as a high-affinity receptor for the TNF family ligands TNFSF13/APRIL and TNFSF13B/BAFF/BLYS.
• Upon ligand binding, CD267/TACI mediates calcineurin-dependent activation of NF-AT, as well as activation of the NF-kappa-B and AP-1 transcription factors.
• This receptor plays a key role in stimulating B- and T-cell functions and regulating humoral immunity.
• CD267/TACI is a membrane-bound protein, consistent with its receptor function.
• It contains transmembrane domains and disulfide bonds, characteristic of the TNF receptor superfamily.
• Keywords associated: Adaptive immunity, immunity, membrane, receptor, signal-anchor, transmembrane helix.

Experimental Guidance and Technical Tips

• This antibody was generated using a recombinant fusion protein covering amino acids 5-129 of mouse CD267/TACI (NP_067324.1). Users may consider verifying epitope specificity in their assay system.
• As a flow cytometry (FC)-validated antibody, it is suitable for cell surface staining; protocols should be optimized for the target cell type.
• The ABflo 647 conjugate allows fluorescence detection in far-red channels; ensure compatibility with instrument configurations and compensation in multicolor panels.
• For optimal performance, titrate the antibody to determine the ideal concentration for specific sample types.
• Ensure proper isotype controls and Fc-blocking steps are included to minimize non-specific binding.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with streamlined access to IVD raw materials. This anti-CD267/TACI antibody supports immunology research focusing on adaptive immunity and B/T cell function, particularly for flow cytometry applications. Beyond this product, we offer comprehensive sourcing of validated antibody pairs, bulk monoclonal and polyclonal antibodies, ancillary reagents, and assistance with rare target raw-material procurement to accelerate your diagnostic development from concept to clinic.