Rabbit anti-Mouse CD267/TACI Monoclonal Antibody for FC - Q9ET35

Core Product Specifications and Parameters

Biological Background: CD267/TACI Function and Localization

• CD267/TACI, also referred to as Transmembrane activator and CAML interactor, is encoded by the Tnfrsf13b gene and belongs to the tumor necrosis factor receptor superfamily (TNFRSF13B).
• It functions as a high-affinity receptor for the TNF superfamily ligands APRIL (TNFSF13) and BAFF (TNFSF13B/TALL1/BLYS).
• Upon ligand binding, TACI triggers downstream signaling cascades, including NF-kappa-B, AP-1, and calcineurin-dependent NF-AT pathways.
• TACI plays a pivotal role in adaptive immunity by stimulating B- and T-cell activation and regulating humoral immune responses.
• Structurally, TACI is a membrane-anchored receptor with a signal-anchor sequence, a single transmembrane helix, and extracellular cysteine-rich repeat domains stabilized by disulfide bonds.
• It is implicated in maintaining immune cell homeostasis; defects in TACI are associated with primary immunodeficiency disorders (By similarity).

Experimental Guidance and Technical Tips

• For flow cytometry (FC), evaluate the optimal antibody titration for your specific mouse cell population and experimental conditions.
• Validate reactivity in mouse samples; cross-reactivity with other species has not been tested.
• Include appropriate isotype controls and consider Fc receptor blocking to reduce background staining.
• Handle the antibody under ice bag conditions to maintain conjugate stability.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers with a streamlined one-stop platform for IVD raw materials, including validated antibody pairs, optimized monoclonal antibodies, and bulk reagents supporting immune receptor research like CD267/TACI. Our comprehensive supply chain assists clients in sourcing rare-target reagents and ancillary materials, smoothing the path from concept to clinic. Contact us to explore how CamelBio can accelerate your diagnostic development with high-quality, reliable products.