Rabbit anti-Mouse CD267/TACI Monoclonal Antibody for FC - Q9ET35

Core Product Specifications and Parameters

Biological Background: CD267/TACI Function and Localization

• CD267/TACI (Transmembrane activator and CAML interactor) is encoded by the Tnfrsf13b gene in mouse and belongs to the tumor necrosis factor receptor superfamily.
• Acts as a high-affinity receptor for TNFSF13/APRIL and TNFSF13B/BAFF/BLyS, key regulators of B-cell survival and differentiation.
• Mediates calcineurin-dependent NF-AT, NF-kappa-B, and AP-1 signaling pathways, linking to broad immune cell activation (By similarity).
• Plays a critical role in B- and T-cell function and the regulation of humoral immunity, influencing antibody responses and class switching (By similarity).
• Localized to the cell membrane with a transmembrane helix, featuring a signal-anchor and disulfide bonds.
• Contains characteristic repeat motifs and undergoes post-translational modifications that contribute to its structural stability.
• The mature protein has a molecular weight of approximately 27 kDa (26947 Da).

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 5-129, covering the N-terminal extracellular domain; consider using standard cell surface staining protocols for flow cytometry.
• For FC, validate the antibody in relevant mouse samples such as splenocytes, lymph node cells, or transfected cell lines expressing CD267/TACI.
• Ensure proper isotype controls and Fc receptor blocking steps are included to minimize non-specific binding in flow cytometry assays.

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CamelBio provides a comprehensive sourcing platform for IVD raw materials, connecting diagnostic manufacturers and research institutes with high-quality reagents like this CD267/TACI monoclonal antibody. Our portfolio includes validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare-target raw material sourcing to support immunology and diagnostic development. Partner with CamelBio to streamline your procurement from concept to clinic.