Rabbit anti-Mouse CD262/TRAILR2 Monoclonal Antibody for Flow Cytometry - Q9QZM4

Core Product Specifications and Parameters

Biological Background: CD262/TRAILR2 Function and Localization

• CD262/TRAILR2, also known as death receptor 5 (DR5) or MK, is the receptor for the cytotoxic ligand TNFSF10/TRAIL.
• Upon TRAIL binding, it recruits the adaptor FADD and caspase-8 to form the death-inducing signaling complex (DISC), leading to caspase activation and apoptosis.
• It also promotes activation of NF-kappa-B and is essential for ER stress-induced apoptosis.
• The protein is localized to the membrane and belongs to the tumor necrosis factor receptor superfamily.
• It is highly expressed in heart, lung, and kidney tissues.
• The receptor is a glycoprotein with a signal peptide, disulfide bonds, and a single transmembrane helix.

Experimental Guidance and Technical Tips

• This -conjugated antibody is suitable for flow cytometry detection of mouse CD262/TRAILR2; optimize the antibody dilution for your specific experimental conditions.
• Include appropriate isotype controls and viability dyes to discriminate specific staining and dead cells.
• Protect the antibody from light to maintain fluorophore stability during storage and staining.
• The immunogen corresponds to the extracellular region (aa 53-170); thus, the antibody is expected to recognize the extracellular domain.
• Cross-reactivity with other species has not been provided; validate if used beyond mouse samples.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to high-quality IVD raw materials, including validated monoclonal antibodies like this anti-CD262/TRAILR2 clone. Our supply capabilities encompass optimized antibody pairs, ancillary reagents, and rare-target sourcing to support your apoptosis and receptor signaling studies. Partner with us for scalable, reliable material procurement from concept to clinic.