Rabbit anti-Mouse CD262/TRAILR2 Monoclonal Antibody for FC - Q9QZM4

Core Product Specifications and Parameters

Biological Background: Tumor necrosis factor receptor superfamily member 10B Function and Localization

• Alternative names include Death receptor 5 (DR5), MK, and KILLER, identifying it as a member of the TNF receptor superfamily.
• Serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL; upon binding, it recruits FADD and caspase-8 to form the death-inducing signaling complex (DISC), triggering the caspase cascade that mediates apoptosis.
• Promotes the activation of NF-kappa-B, linking death receptor signaling to inflammatory and survival pathways.
• Plays an essential role in ER stress-induced apoptosis, highlighting its involvement in cellular stress responses.
• Localized to the cell membrane as a single-pass type I transmembrane protein, with an extracellular domain responsible for ligand binding.
• Contains characteristic structural features including a signal peptide, three cysteine-rich repeats, a transmembrane helix, and a cytoplasmic death domain, and is subject to post-translational modifications such as disulfide bond formation and glycosylation.
• Highly expressed in heart, lung, and kidney, suggesting tissue-specific regulatory functions.

Experimental Guidance and Technical Tips

• The immunogen, corresponding to amino acids 53–170 of the extracellular domain, is predicted to generate antibodies recognizing cell-surface CD262/TRAILR2.
• As a directly conjugated antibody (), it is ready for flow cytometry without secondary labeling; consider titrating to determine the optimal concentration for your cell type.
• Include appropriate isotype controls, viability dyes, and Fc receptor blocking steps to ensure specific staining and minimize background.
• For quantitative analysis, use cells with known expression levels (e.g., heart, lung, or kidney cell lines) or positive controls treated with ER stress inducers.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research institutions as a comprehensive IVD raw-material partner. This antibody targets the apoptosis-related receptor CD262/TRAILR2, relevant for oncology and cell death studies. Beyond this product, CamelBio provides validated antibody pairs, custom monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare-target sourcing to streamline your assay development and production workflows.