Rabbit anti-Mouse CD24 Monoclonal Antibody for IF/FC - P24807

Core Product Specifications and Parameters

Biological Background: CD24 Function and Localization

• Signal transducer CD24, also known as heat stable antigen (HSA) or nectadrin, is a small GPI-anchored glycoprotein expressed on lymphoid, myeloid, and erythroid cells.
• It may play a pivotal role in cell differentiation and early thymocyte development, with signaling triggered by lectin-like ligand binding to its carbohydrates and transduced via GPI-anchor second messengers.
• CD24 modulates B-cell activation responses (By similarity).
• In association with SIGLEC10, CD24 is involved in the selective suppression of immune responses to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70, and HSP90. Related references: PMID:19264983
• It plays a role in the control of autoimmunity, as demonstrated in mouse models. Related references: PMID:20200274
• The protein localizes to the cell membrane via a GPI-anchor and is categorized under keywords including immunity, innate immunity, glycoprotein, and lipoprotein.

Experimental Guidance and Technical Tips

• The immunogen spans the extracellular domain (amino acids 27-53), making this antibody suitable for detecting surface CD24 by flow cytometry or immunofluorescence.
• For intracellular staining, permeabilization protocols may be required; consider validating in your specific cell system.
• As a directly conjugated antibody, it can be used in multiplexed experiments without secondary antibodies; titrate and optimize staining conditions for best signal-to-noise ratio.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a one-stop sourcing solution for IVD raw materials, offering this high-quality anti-CD24 monoclonal antibody to support your immunology and cell biology research. Alongside this product, we supply validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing. Partner with CamelBio to streamline your diagnostic development pipeline from concept to clinic.