Rabbit anti-Mouse CD201/EPCR Monoclonal Antibody for Flow Cytometry - Q64695

Core Product Specifications and Parameters

Biological Background: Endothelial protein C receptor Function and Localization

• Also known as activated protein C receptor, centrocyclin, or centrosomal protein CCD41; encoded by the Procr gene in mouse.
• Binds activated protein C and enhances its activation by the thrombin-thrombomodulin complex, playing an essential role in the protein C anticoagulant pathway.
• Functions as a transmembrane receptor that controls blood coagulation and hemostasis.
• Localized to the plasma membrane, consistent with its role in cell surface binding and signaling.
• Expressed specifically in endothelial cells, where it regulates thrombotic and inflammatory responses.
• Contains structural features including a signal peptide, an extracellular ligand-binding domain, a single transmembrane helix, and a short cytoplasmic tail; classified as a glycoprotein with a disulfide bond.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 18–210) corresponds to the extracellular domain, making this antibody well-suited for detecting native cell surface EPCR by flow cytometry.
• Direct conjugation to eliminates the need for secondary antibodies, simplifying the staining protocol and reducing background.
• Validate in appropriate mouse endothelial cell lines or primary endothelial cells; consider including a positive control tissue such as mouse lung or heart.
• As the antibody is specific for mouse CD201/EPCR, do not expect cross-reactivity with other species unless independently verified.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your dedicated one-stop partner for IVD raw-material sourcing, supplying high-quality antibodies like this anti-CD201/EPCR clone for hemostasis research and diagnostic development. Our portfolio includes validated antibody pairs, bulk ancillary reagents, and custom sourcing for rare targets, supported by expert technical consultation from concept to clinic.