Rabbit anti-Mouse CD201/EPCR Monoclonal Antibody for FC - Q64695

Core Product Specifications and Parameters

Biological Background: Endothelial protein C receptor Function and Localization

• Endothelial protein C receptor (EPCR), encoded by the PROCR gene (also known as Epcr), is also referred to as centrocyclin or centrosomal protein CCD41.
• EPCR specifically binds activated protein C and enhances protein C activation by the thrombin-thrombomodulin complex, playing a critical role in the protein C pathway that controls blood coagulation.
• As a membrane receptor, EPCR is localized on the cell surface and contains a transmembrane helix, signal peptide, and disulfide bond-stabilized extracellular domain.
• This glycoprotein is expressed in endothelial cells, consistent with its role in hemostasis and vascular biology.
• Keywords associated with EPCR include blood coagulation, hemostasis, membrane, receptor, and glycoprotein, reflecting its function in anticoagulant pathways.

Experimental Guidance and Technical Tips

• The immunogen covers the extracellular domain (aa 18-210) of mouse EPCR, making it suitable for detecting surface-expressed EPCR by flow cytometry.
• For FC, consider titrating the antibody to determine the optimal concentration for your specific mouse cell type.
• Validate the antibody's reactivity with mouse endothelial cells or EPCR-transfected cells to confirm specificity.
• As a directly conjugated antibody (), it eliminates the need for secondary staining, reducing background and simplifying multi-color panels.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines IVD raw-material procurement for diagnostic developers and researchers. For coagulation and hemostasis targets like CD201/EPCR, we offer a range of validated antibodies, antigen pairs, and ancillary reagents to support assay development. Explore our catalog or contact us for tailored sourcing of rare-target raw materials and one-stop technical consulting.