Rabbit anti-Mouse CD105/Endoglin mAb for Flow Cytometry - Q63961

Core Product Specifications and Parameters

Biological Background: CD105/Endoglin Function and Localization

• Endoglin is a vascular endothelium glycoprotein that plays a critical role in the regulation of angiogenesis (PubMed:10625534) and is required for normal structure and integrity of adult vasculature (By similarity). Related references: PMID:10625534
• Regulates the migration of vascular endothelial cells (PubMed:17540773). Related references: PMID:17540773
• Required for normal extraembryonic angiogenesis and embryonic heart development (PubMed:10625534). Related references: PMID:10625534
• May regulate endothelial cell shape changes in response to blood flow, driving vascular remodeling and establishment of normal vascular morphology (PubMed:28530658). Related references: PMID:28530658
• Acts as a TGF-beta coreceptor, involved in TGF-beta/BMP signaling and SMAD transcription factor activation (PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 and modulates TGFB1 signaling through SMAD3 (By similarity). Related references: PMID:23300529
• Localizes to the cell membrane.
• Detected on blood vessels and restricted to endothelial cells in most tissues; also found in bone marrow stromal cells and connective tissue of intestine, stomach, heart, skeletal muscle, uterus, ovary, oviduct, testis, and thymus (PubMed:8194490). Related references: PMID:8194490
• Belongs to a group of proteins involved in angiogenesis, cell adhesion, and signaling; features disulfide bonds, glycosylation, and phosphorylation sites.

Experimental Guidance and Technical Tips

• The immunogen is a recombinant fusion protein spanning the extracellular domain (amino acids 27-581) of mouse CD105, which may contribute to specificity for native surface-expressed endoglin.
• This antibody is validated for flow cytometry on mouse samples. Consider titrating the antibody to optimize staining and include appropriate isotype controls.
• For intracellular detection, ensure proper permeabilization steps, though endoglin is primarily a membrane protein.
• Validate the antibody in your specific experimental model system, as performance may vary with cell type and activation status.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers, labs, and research institutes a comprehensive one-stop platform for IVD raw materials, technical services, and consulting—supporting you from concept to clinic. For researchers exploring angiogenesis and vascular biology, this anti-CD105/Endoglin antibody exemplifies our diverse portfolio of validated monoclonal antibodies. Whether you need bulk ancillary reagents, custom antibody development, or rare target sourcing, our team streamlines your procurement and accelerates your development pipeline.