Rabbit anti-Human/Mouse CD351/FCAMR mAb - Q8WWV6

Core Product Specifications and Parameters

Biological Background: CD351/FCAMR Function and Localization

• FCAMR encodes the high affinity immunoglobulin alpha and mu Fc receptor, also known as CD351, which functions as a receptor for the Fc region of both IgA and IgM. It binds these immunoglobulins with high affinity and mediates their endocytosis, implicating it in mucosal and systemic immune defense against microbes.
• The receptor is a type I transmembrane protein containing an extracellular region with immunoglobulin-like domains, a single transmembrane helix, and a short cytoplasmic tail. The immunogen used for this antibody corresponds to the entire extracellular domain (amino acids 17–450) of the canonical isoform Q8WWV6-1.
• Subcellular localization is primarily at the cell membrane, consistent with its role in recognizing extracellular antibodies and facilitating their internalization.
• Tissue-specific expression has been reported in mesangial cells of the kidney, suggesting a role in clearing immune complexes from the glomerular basement membrane.
• Post-translational processing includes signal peptide removal (residues 1–16), disulfide bond formation, and N-linked glycosylation, all contributing to proper folding and surface expression.
• Alternative splicing generates multiple transcript variants; this antibody targets the full-length receptor expressed on the cell surface.
• UniProt keywords highlight involvement in adaptive immunity, immunoglobulin-mediated signaling, and potential proteomics applications for receptor identification.

Experimental Guidance and Technical Tips

• The immunogen spanning the entire extracellular domain (17–450) suggests the antibody likely recognizes native epitopes presented on live cells, supporting its use in flow cytometry (FC) without permeabilization.
• Given cross-reactivity with mouse FCAMR, consider this antibody for comparative studies in human and mouse models, but validate specificity in the relevant species background.
• Optimal antibody dilution and staining conditions should be determined experimentally by titrating the antibody on the cell type of interest, using appropriate positive and negative controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-CD351/FCAMR monoclonal antibody is part of our expanding portfolio of Fc receptor-targeting reagents, supporting immune function research and therapeutic antibody development. Beyond validated antibody pairs and optimized monoclonal antibodies, CamelBio offers bulk ancillary reagents and rare target raw-material sourcing to streamline your procurement process.