Rabbit anti-Human/Monkey CD20 mAb for FC - P12314

Core Product Specifications and Parameters

Biological Background: High affinity immunoglobulin gamma Fc receptor I Function and Localization

• FCGR1A encodes the high affinity immunoglobulin gamma Fc receptor I, also known as Fc-gamma RI or FcgammaRIa, which binds IgG with high affinity.
• It is a member of the immunoglobulin superfamily and functions as a key receptor in both innate and adaptive immune responses.
• Upon engagement with IgG, FCGR1A mediates antibody-dependent cellular cytotoxicity (ADCC) in monocytes, contributing to the clearance of virus-infected cells.
• The receptor is specifically expressed on the cell membrane of monocytes and macrophages, as evidenced by its tissue specificity.
• Post-translational modifications include glycosylation and phosphorylation, as indicated by keywords; these likely modulate receptor signaling and stability.
• Alternative splicing generates isoforms, potentially affecting receptor function or expression.
• Keywords also suggest involvement in immunity, receptor activity, and proteomics identification, highlighting its biological significance.

Experimental Guidance and Technical Tips

• This conjugate is designed for direct flow cytometry; consider titrating the antibody to determine the optimal concentration for your specific sample and instrument settings.
• Given the cross-reactivity with cynomolgus, this antibody may be suitable for translational studies; validate in the relevant species model to confirm performance.
• The immunogen is a synthetic peptide within the 100-200 region of human CD20; if you are investigating specific epitopes, further mapping may be required.
• For multicolor panels, assess compensation and spillover to ensure accurate data analysis.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio connects diagnostic manufacturers and research teams with a comprehensive portfolio of IVD raw materials, including validated antibody pairs and optimized monoclonal antibodies like this anti-CD20 conjugate for immune cell profiling. Our supply chain extends to bulk ancillary reagents and rare target sourcing, supporting your workflow from early research to clinical assay development. Partner with us to streamline your raw material procurement and accelerate your project timelines.