Rabbit Anti-Human TROP-2 Monoclonal Antibody () for Flow Cytometry - P09758

Core Product Specifications and Parameters

Biological Background: TROP-2 Function and Localization

• TROP-2 (Tumor-associated calcium signal transducer 2), also known as cell surface glycoprotein Trop-2, EGP1, or GA733-1, is encoded by the TACSTD2 gene.
• It is a cell surface glycoprotein that may function as a growth factor receptor, playing a role in cell proliferation and signaling.
• TROP-2 is a transmembrane protein localized to the membrane, with a signal peptide, a large extracellular domain, a single transmembrane helix, and a short cytoplasmic tail.
• The protein is expressed in trophoblast cells of the placenta and in various epithelial cancers, including pancreatic carcinoma cell lines, making it a recognized tumor antigen.
• Post-translational modifications include glycosylation and disulfide bond formation, contributing to its stability and function on the cell surface.
• TROP-2 has been implicated in corneal dystrophy and amyloidosis, as indicated by its association with these conditions in the UniProt keywords.
• Keywords also highlight its role in sensory transduction and vision, though these functions may be context-dependent.

Experimental Guidance and Technical Tips

• As a monoclonal antibody conjugated to , this product is suitable for flow cytometry (FC) applications; consider titrating the antibody to determine the optimal working concentration for your specific assay.
• The immunogen corresponds to the extracellular domain (amino acids 27-274) of human TROP-2; ensure your sample system expresses TROP-2, such as placental tissues or pancreatic carcinoma cell lines.
• Since this antibody is rabbit-derived and targets human TROP-2, use appropriate isotype controls and human Fc receptor blocking to minimize non-specific binding in FC experiments.
• For best results, validate the antibody in your relevant sample system and follow standard protocols for cell staining with fluorochrome-conjugated antibodies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides one-stop sourcing for IVD raw materials, technical services, and consulting to bridge your product development from concept to clinic. This anti-TROP-2 monoclonal antibody supports cancer biomarker research and diagnostic assay development. We offer validated antibody pairs, bulk raw materials, and customized sourcing for rare targets to streamline your IVD manufacturing pipeline.