Rabbit anti-Human TROP-2 Monoclonal Antibody for Flow Cytometry - P09758

Core Product Specifications and Parameters

Biological Background: TROP-2 Function and Localization

• TROP-2, encoded by the TACSTD2 gene, is a cell surface glycoprotein also known as tumor-associated calcium signal transducer 2, GA733-1, and M1S1.
• It is a transmembrane protein, localized to the membrane, and contains a signal peptide and a transmembrane helix.
• TROP-2 is a tumor antigen, expressed in various carcinomas, notably in pancreatic carcinoma cell lines, and is also found in the placenta.
• May function as a growth factor receptor, involved in signal transduction.
• Post-translational modifications include glycosylation and disulfide bond formation.
• UniProt keywords also link TROP-2 to amyloidosis, corneal dystrophy, and sensory transduction, suggesting potential roles in these processes.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (amino acids 27-274), making this antibody suitable for detecting surface TROP-2 in live cell flow cytometry.
• Validate the antibody in your cell system of interest, such as human pancreatic carcinoma cell lines known to express TROP-2.
• Consider titrating the antibody to determine the optimal concentration for your flow cytometry assay, and include appropriate isotype controls.
• Store the antibody as recommended, avoiding repeated freeze-thaw cycles to maintain conjugate stability.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research institutes a comprehensive portfolio of IVD raw materials, including validated antibody pairs, monoclonal and polyclonal antibodies, and bulk ancillary reagents. This anti-TROP-2 antibody supports cancer biomarker research and assay development, and we can assist with customized sourcing for rare or specialized targets. From discovery to clinical application, CamelBio is your reliable partner in raw-material supply and technical support.