Rabbit anti-Human TNFRSF10D/TRAILR4 Monoclonal Antibody for FC - Q9UBN6

Core Product Specifications and Parameters

Biological Background: TNFRSF10D/TRAILR4 Function and Localization

• TNFRSF10D encodes decoy receptor 2 (DcR2), also known as TRAIL-R4 and TRUNDD, a member of the tumor necrosis factor receptor superfamily.
• It functions as a receptor for TRAIL (TNF-related apoptosis-inducing ligand) but contains a truncated death domain, rendering it incapable of inducing apoptosis. Related references: PMID:9430226 PMID:9537512
• Instead, it acts as a protective decoy receptor that antagonizes TRAIL-mediated apoptosis. Related references: PMID:9537512
• Reports on NF-kappa-B pathway activation are contradictory: some studies show no induction, while others suggest it can activate NF-kappa-B. Related references: PMID:9382840 PMID:9430226
• The protein is a transmembrane glycoprotein localized to the cell membrane, with features such as a signal peptide, disulfide bonds, and multiple repeat regions.
• It is widely expressed, with highest levels in fetal kidney, lung, liver, and adult testis and liver; also found in leukocytes, colon, small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta, and heart.
• Gene family: TNFRSF10D (Gene ID: 8793) belongs to the TNF receptor superfamily.

Experimental Guidance and Technical Tips

• This rabbit monoclonal antibody is directly conjugated to , a bright and photostable fluorophore, enabling straightforward flow cytometry without secondary staining.
• The immunogen spans the extracellular domain (aa 56–211), suggesting the antibody likely targets surface-exposed epitopes, suitable for live-cell staining.
• Validate specificity using appropriate isotype controls and consider competitive binding assays with recombinant TRAIL to confirm epitope accessibility.
• Cross-reactivity is listed as Human; if using in other species, perform preliminary testing and verify expression before experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with a seamless supply chain for IVD raw materials, including validated monoclonal antibodies like this anti-TNFRSF10D/TRAILR4 clone. Whether you need matched antibody pairs, bulk ancillary reagents, or rare target sourcing, our platform supports your program from concept to clinic. Contact us for tailored procurement solutions and technical consultation to accelerate your apoptosis or oncology IVD development.