Rabbit anti-Human Syndecan 4 Monoclonal Antibody for FC - P31431

Core Product Specifications and Parameters

Biological Background: Syndecan-4 Function and Localization

• Syndecan-4 (SDC4) is a cell surface heparan sulfate proteoglycan, also known as amphiglycan or ryudocan core protein, encoded by the SDC4 gene in humans (GeneID: 6385).
• Functions as a key regulator of exosome biogenesis, acting in concert with SDCBP and PDCD6IP (PubMed:22660413). Related references: PMID:22660413
• Localizes to the membrane and is also secreted, consistent with its roles in cell surface signaling and extracellular matrix interactions.
• Expressed in fibroblasts and epithelial cells, as detected at the protein level (PubMed:1500433, PubMed:36213313). Related references: PMID:1500433 PMID:36213313
• Undergoes alternative splicing and is post-translationally modified by glycosylation, including attachment of heparan sulfate chains, critical for ligand binding.
• Annotated with keywords including 3D-structure, glycoprotein, heparan sulfate, proteoglycan, and reference proteome.

Experimental Guidance and Technical Tips

• The immunogen encompasses the extracellular domain (amino acids 19–145), suggesting the antibody likely recognizes an epitope in this region, suitable for detecting surface Syndecan-4 by flow cytometry.
• For FC applications, titrate the antibody to determine the optimal concentration for your specific cell type and experimental conditions.
• Consider using appropriate isotype controls to assess non-specific binding.
• Validate performance in the relevant sample system (e.g., fibroblasts or epithelial cell lines) to confirm specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-Syndecan 4 antibody supports research in exosome biology and cell surface proteoglycan studies. Beyond this product, CamelBio offers validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to streamline your assay development.