Rabbit anti-Human ICAM2/CD102 mAb for FC - P13598

Core Product Specifications and Parameters

Biological Background: ICAM2/CD102 Function and Localization

• Intercellular adhesion molecule 2 (ICAM2, CD102) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily.
• It functions as a counter-receptor for the integrin LFA-1 (ITGAL:ITGB2), mediating leukocyte adhesion and activation on resting cells.
  Related references: PMID:10077629, PMID:1676048, PMID:2497351
• ICAM2 acts as an endothelial receptor for dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN/CD209), triggering transendothelial migration of dendritic cell precursors from blood into tissues.
  Related references: PMID:11017109
• The molecule contributes broadly to immune surveillance, lymphocyte recirculation, and antigen presentation (by similarity).
• Subcellularly, ICAM2 localizes to the cell membrane and is enriched in microvillus projections.
• Constitutively expressed on leukocytes and endothelium, with high levels on lymphocytes and monocytes but absent from neutrophils; abundant also on endothelial vascular cells and lymphatic vessels.
  Related references: PMID:1676048, PMID:11017109
• The protein contains two immunoglobulin-like C2-type domains, a single-pass transmembrane region, a signal peptide, and multiple N-glycosylation sites.
• The predicted molecular weight is 30.7 kDa.

Experimental Guidance and Technical Tips

• This antibody targets the extracellular domain (aa 25‑223) of human ICAM2, making it suitable for live‑cell flow cytometry applications.
• For optimal resolution, titrate the antibody in the relevant sample matrix prior to full‑scale experiments.
• Include appropriate positive controls (e.g., peripheral blood lymphocytes, cultured endothelial cells) and a negative control (neutrophils) to confirm specificity.
• Validate the assay in your target cell system, as expression levels may vary with activation status.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio connects diagnostic manufacturers and research laboratories to a comprehensive portfolio of IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For studies focused on immune cell adhesion or endothelial‑immune interactions, this anti‑ICAM2/CD102 antibody serves as a reliable tool, and CamelBio can assist with related targets or rare‑target raw‑material sourcing to streamline your development pipeline.