Rabbit anti-Human GP6/GPVI Monoclonal Antibody for Flow Cytometry - Q9HCN6

Core Product Specifications and Parameters

Biological Background: GP6/GPVI Function and Localization

• Platelet glycoprotein VI (GP6/GPVI) is a key collagen receptor on platelets that mediates collagen-induced platelet adhesion, activation, and subsequent thrombus formation.
• GP6 signaling involves the FcR gamma-chain, Src kinases (FYN or LYN), SYK, LAT, and PLCG2, leading to platelet procoagulant activity and thrombin generation.
• This receptor is essential for hemostasis and contributes to both arterial and venous thrombosis, linking it to vascular disease.
• GP6 is highly expressed in megakaryocytes and platelets and localizes to the cell membrane, where it engages extracellular matrix collagen.
• Structurally, GP6 features immunoglobulin-like domains, disulfide bonds, and glycosylation; alternative splicing generates distinct isoforms.
• The protein is implicated in platelet-related disorders and serves as a target for antithrombotic therapy.

Experimental Guidance and Technical Tips

• For optimal flow cytometry results, titrate the -conjugated antibody against your target cell population to determine the ideal staining dilution.
• Validate the antibody on human platelet-rich plasma or isolated platelets, employing Fc receptor blocking to minimize background.
• Employ a gating strategy that includes forward/side scatter and a platelet-specific marker (e.g., CD61) to ensure accurate identification of the platelet population.
• When performing multicolor flow cytometry, compensate for spectral overlap and include fluorescence-minus-one controls.

CamelBio: Your One-Stop Sourcing Bridge

This anti-GP6/GPVI monoclonal antibody is offered through CamelBio’s comprehensive raw-material supply for platelet and thrombosis diagnostics. With capabilities spanning validated antibody pairs, bulk conjugates, and rare target sourcing, we serve as a one-stop partner from assay concept to clinical development.