Rabbit anti-Human CD98 Monoclonal Antibody for FC - P08195

Core Product Specifications and Parameters

Biological Background: CD98 Function and Localization

• SLC3A2 acts as a chaperone, facilitating biogenesis and plasma membrane trafficking of SLC7 family amino acid transporters. Related references: PMID:10574970, PMID:10903140, PMID:11557028

• The SLC3A2/SLC7A5 heterodimer mediates transport of neutral amino acids, thyroid hormones, and L-DOPA, and SLC3A2 is essential for SLC7A5 surface expression and activity. Related references: PMID:10574970, PMID:11389679, PMID:11557028, PMID:10391915, PMID:11311135

• The SLC3A2/SLC7A11 heterodimer functions as an antiporter exchanging extracellular L-cystine for intracellular L-glutamate, crucial for cellular redox homeostasis. Related references: PMID:34880232

• SLC3A2/SLC7A6 and SLC3A2/SLC7A7 mediate uptake of dibasic amino acids. Related references: PMID:10903140, PMID:9829974

• When in complex with LAPTM4B, SLC3A2/SLC7A5 is directed to lysosomes to import leucine and activate mTORC1 signaling. Related references: PMID:25998567

• SLC3A2 modulates integrin-dependent cell spreading, migration, and tumor progression. Related references: PMID:11121428, PMID:15625115

• Subcellularly, SLC3A2 localizes to the apical and basolateral cell membrane, lysosome membrane, melanosome, and cell junctions; expressed ubiquitously with highest levels in kidney, placenta, and testis.

• Acts as a receptor for Plasmodium vivax in immature red blood cells and facilitates HCV entry; heavily glycosylated with multiple post-translational modifications.

Experimental Guidance and Technical Tips

• The immunogen covers the extracellular domain (amino acids 206–630), which may facilitate recognition of native epitopes; consider titrating the antibody to determine optimal staining concentration in your cell system.
• This antibody is validated for flow cytometry (FC); for surface staining, ensure cells are viable and block non-specific binding with appropriate serum or Fc block.
• If intracellular staining is required, a permeabilization step may be necessary, though the conjugate is primarily intended for live-cell surface detection.
• Since CD98 forms heterodimers with multiple SLC7 light chains, co-expression analysis with relevant SLC7 family members could provide additional functional insights.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers one-stop access to IVD raw materials, including validated monoclonal antibodies like this anti-CD98 clone. Whether you are investigating amino acid transport, integrin signaling, or viral entry mechanisms, our portfolio supports your development needs with bulk ancillary reagents and expert sourcing for rare targets. From concept to clinic, we bridge the gap between research and diagnostic manufacturing.