Rabbit anti-Human CD93 mAb for FC - Q9NPY3

Core Product Specifications and Parameters

Biological Background: CD93 Function and Localization

• CD93 (Complement component C1q receptor, C1qR) is a cell surface receptor that mediates phagocytosis and enhances uptake of apoptotic cells and immune complexes by binding defense collagens such as surfactant protein A (SFTPA1), C1q, and mannose-binding lectin (MBL2).
  Related references:
  PMID:7977768

• In endothelial cells, CD93 promotes angiogenesis by associating with β-dystroglycan, leading to SRC-dependent phosphorylation and recruitment of CBL, which provides a docking site for CRKL to drive cell migration.
  Related references:
  PMID:24809468, PMID:26848865

• CD93 also acts as a receptor for the extracellular matrix glycoproteins multimerin-2 (MMRN2) and IGFBP7, both of which are required for CD93-mediated endothelial cell function.
  Related references:
  PMID:28671670, PMID:36265539, PMID:38218180

• The protein regulates endothelial barrier integrity by modulating VEGFR2 signaling. (By similarity)

• CD93 is expressed predominantly on the cell membrane and is highly tissue-specific: it is found in endothelial cells, platelets, and myeloid lineage cells (monocytes, neutrophils) but not in lymphoid cells.

• Structurally, CD93 features EGF-like domains, is heavily glycosylated, and contains disulfide bonds and phosphorylation sites, consistent with its role as a transmembrane signaling receptor.

Experimental Guidance and Technical Tips

• The antibody is directly conjugated to , making it suitable for direct flow cytometry (FC) detection of human CD93.
• The immunogen corresponds to the extracellular domain (aa 24-580), ensuring recognition of the native membrane form; consider titrating the antibody for optimal staining in FC assays.
• For FC experiments, include appropriate isotype controls and Fc receptor blocking steps when working with myeloid cell samples.
• Validate the antibody performance in your specific cellular system, as CD93 expression levels vary among endothelial and immune cell populations.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, research institutes, and laboratories with integrated access to premium IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents for inflammation and vascular biology research. Our one-stop sourcing model supports every stage of assay development—from concept to clinic—with a special focus on rare and emerging targets such as CD93. We streamline procurement to accelerate your diagnostic and research workflows.