Rabbit anti-Human CD87/PLAUR Monoclonal Antibody for FC - Q03405

Core Product Specifications and Parameters

Biological Background: CD87/PLAUR Function and Localization

• GPI-anchored receptor that binds urokinase-type plasminogen activator (uPA) with high affinity, concentrating its proteolytic activity at the cell surface to convert plasminogen into plasmin, thereby initiating extracellular matrix degradation and remodeling. Related references: PMID:1689240, PMID:15677461
• Serves as an adhesion receptor by binding vitronectin in the extracellular matrix, which promotes cell-matrix adhesion and indirectly triggers integrin signaling. Related references: PMID:17548516, PMID:25168639, PMID:28849762
• Coordinates dynamic changes in cell migration, proliferation, and tissue remodeling by integrating uPA proteolysis and vitronectin adhesion. Related references: PMID:28849762
• Alternative splicing generates multiple isoforms; the full-length GPI-anchored form is predominantly membrane-bound, while soluble forms can be secreted.
• Localized primarily to the cell membrane and invadopodium membrane; also detected in a secreted form.
• Expressed in neurons of the rolandic area of the brain (at protein level) and in other tissues.
• Keywords: 3D-structure, Alternative splicing, Cell junction, Cell membrane, Cell projection, Direct protein sequencing, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Membrane, Proteomics identification, Receptor, Reference proteome, Repeat, Secreted, Signal.

Experimental Guidance and Technical Tips

• The immunogen spans the extracellular domain (aa 23–303), suggesting the antibody recognizes the native receptor; consider use in flow cytometry for surface staining of live cells.
• For optimal FC performance, titrate the antibody and include appropriate isotype controls. Validate staining in the relevant human sample system expressing CD87/PLAUR.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with a one-stop supply of IVD raw materials, from validated antibody pairs and optimized monoclonal/polyclonal antibodies to bulk ancillary reagents. Our portfolio includes targets like CD87/PLAUR for cancer and cell adhesion research, supporting your assay development with reliable sourcing and technical expertise. Contact us to bridge your concept to clinic efficiently.