Rabbit anti-Human CD7 Monoclonal Antibody for FC - P09564

Core Product Specifications and Parameters

Biological Background: CD7 Function and Localization

• CD7 is a transmembrane glycoprotein also known as GP40, T-cell leukemia antigen, T-cell surface antigen Leu-9, and TP41.
• It is expressed on T-cells, natural killer (NK) cells, and their precursors. Related references: PMID:7506726
• CD7 acts as a costimulatory molecule in T-cell activation upon binding to its ligand K12/SECTM1, leading to cytokine production such as IL-2. Related references: PMID:10652336, PMID:1709867
• On resting NK cells, CD7 activation induces significant interferon-gamma production. Related references: PMID:7506726
• CD7 localizes to the membrane as a single-pass type I membrane protein.
• The protein contains immunoglobulin-like domains, disulfide bonds, and is glycosylated and palmitoylated.
• The predicted molecular weight is approximately 25.4 kDa.
• CD7 is annotated with keywords including adaptive immunity, receptor, and transmembrane helix.

Experimental Guidance and Technical Tips

• The immunogen covers the extracellular domain (aa 26-180), which may enable detection of surface CD7 in live-cell flow cytometry.
• The antibody is directly conjugated to ; perform titration to optimize staining index for your sample type.
• Validate specificity using relevant cell lines (e.g., Jurkat, CCRF-CEM) or primary human PBMCs; include an appropriate isotype control.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides this Rabbit anti-Human CD7 mAb alongside a comprehensive portfolio of IVD raw materials for immuno-oncology and immune profiling. We offer validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and expert sourcing for rare-target raw materials to support diagnostic development from concept to clinic.