Rabbit anti-Human CD336/NK-p44 mAb for FC - O95944

Core Product Specifications and Parameters

Biological Background: Natural cytotoxicity triggering receptor 2 Function and Localization

• Primary identity: Natural cytotoxicity triggering receptor 2 (also known as NKp44, CD336, LY95), encoded by the NCR2 gene. It is a member of the natural cytotoxicity receptor family.
• Function: Acts as a cytotoxicity-activating receptor that enhances the efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
• Expression: Selectively expressed by activated NK cells and in vitro cultured TCRg/d lymphoid cells; not expressed on resting NK cells.
• Subcellular location: Cell membrane protein with a single-pass transmembrane domain.
• Structural features: Contains an immunoglobulin domain, disulfide bond, and is glycosylated; alternative splicing produces multiple isoforms.
• Keywords: 3D-structure available; classified as a receptor with signal peptide and transmembrane helix.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (amino acids 22-190), which is ideal for targeting the native receptor on the cell surface.
• For flow cytometry, validate the antibody using activated human NK cells as a positive control; resting NK cells can serve as a negative control.
• Since the antibody is pre-conjugated with , consider using a suitable isotype control conjugated to the same fluorophore.
• Ensure cell sample preparation maintains membrane integrity to preserve surface receptor staining.
• Optimize antibody titration to achieve the best signal-to-noise ratio in your specific experimental system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers, research laboratories, and institutes one-stop access to IVD raw materials, technical services, and consulting. This CD336/NK-p44 antibody supports activated NK cell research and tumor immunology workflows. From validated antibody pairs and optimized monoclonal antibodies to bulk ancillary reagents and rare target sourcing, CamelBio streamlines your procurement process from concept to clinic.