Rabbit anti-Human CD335/NKp46 Monoclonal Antibody for FC - O76036

Core Product Specifications and Parameters

Biological Background: CD335/NKp46 Function and Localization

• CD335 (also known as NKp46, LY94) is a natural cytotoxicity triggering receptor (NCR1) encoded by the NCR1 gene in humans.
• It acts as an activating receptor on NK cells, enhancing their ability to lyse tumor cells.
• The protein belongs to the immunoglobulin superfamily and contains extracellular immunoglobulin domains.
• CD335 localizes primarily to the cell membrane via a transmembrane helix.
• It is predicted to be glycosylated and contains disulfide bonds, which are important for structural stability and function.
• The receptor is selectively expressed on both resting and activated natural killer cells.
• Alternative splicing generates multiple isoforms, consistent with observed protein weights ranging from 21 to 34 kDa.
• The precursor includes a signal peptide, and the mature receptor features a cytoplasmic tail; 3D structures have been resolved.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 22–254, covering the extracellular domain, so the antibody likely recognizes the native cell surface receptor.
• For flow cytometry, consider titrating the antibody to determine the optimal concentration and include an appropriate Fc blocking step to reduce non-specific binding.
• Validate performance in the relevant sample system, such as human PBMCs or purified NK cell populations.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive one-stop sourcing solution for IVD raw materials, providing validated monoclonal antibodies like this anti-CD335/NKp46 antibody to support NK cell biology and tumor immunology research. Our portfolio includes ready-to-use antibody pairs, bulk ancillary reagents, and custom sourcing for rare targets, all from a single B2B partner. Contact us to streamline your raw material procurement from concept to clinic.