Rabbit anti-Human CD307b Monoclonal Antibody for FC - Q96LA5

Core Product Specifications and Parameters

Biological Background: CD307b Function and Localization

• Fc receptor-like protein 2 (FCRL2), also known as FcRH2, IFGP4, IRTA4, SPAP1, or CD307b, is a member of the Fc receptor-like family.
• It is predicted to have an immunoregulatory role in normal and neoplastic B cell development.
• Single-pass type I transmembrane receptor localized to the cell membrane, with an extracellular region containing immunoglobulin-like domains.
• Post-translational modifications include N-linked glycosylation and disulfide bond formation, typical for cell surface receptors.
• Expressed specifically in secondary lymphoid organs, such as spleen and lymph node, and restricted to mature B-lineage cells, particularly memory B cells.
• Alternative splicing generates multiple isoforms; isoform 2 is found in spleen, peripheral blood, and bone marrow.
• Keywords from UniProt highlight its structural features: signal peptide, multiple immunoglobulin-like domains, and a transmembrane helix.

Experimental Guidance and Technical Tips

• Consider using this -conjugated antibody for direct flow cytometry analysis of CD307b expression on live B cells.
• Since the immunogen spans the ectodomain, the antibody likely recognizes an extracellular epitope; include appropriate isotype controls and Fc receptor blocking to minimize non-specific binding.
• Validate staining specificity using CD307b-overexpressing cells or by comparing with known expression patterns in memory B-cell subsets.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a streamlined procurement channel for diagnostic-grade antibodies, validated antibody pairs, and ancillary reagents. In the area of B cell immunophenotyping, we can source anti-CD307b antibodies and related research supports to accelerate your assay development.