Rabbit anti-Human CD262/DR5/TRAILR2 Monoclonal Antibody for FC - O14763

Core Product Specifications and Parameters

Biological Background: CD262/DR5/TRAILR2 Function and Localization

• Functions as the receptor for the cytotoxic ligand TNFSF10/TRAIL, triggering apoptosis through the FADD/caspase-8 DISC pathway. Related references: PMID:10549288
• Promotes the activation of NF-kappa-B, linking death receptor signaling to inflammatory and survival pathways.
• Essential for ER stress-induced apoptosis, highlighting its role in cellular stress responses.
• Localizes to the plasma membrane as a single-pass type I transmembrane protein (SUBCELLULAR LOCATION: Membrane).
• Widely expressed in adult and fetal tissues, with particularly high expression in tumor cell lines (HeLaS3, K-562, HL-60, etc.) and organs such as heart, liver, pancreas, spleen, and throughout the intestinal tract; not detected in brain.
• Undergoes alternative splicing, producing multiple isoforms; the protein is glycosylated and contains disulfide bonds (UniProt keywords).

Experimental Guidance and Technical Tips

• The immunogen, amino acids 56-182, covers an extracellular region, favoring antibodies that recognize native cell-surface TRAIL-R2.
• direct conjugate enables flow cytometry without secondary reagents; titrate for optimal staining and validate in relevant human cell lines or primary cells.
• Given alternative splicing, confirm isoform reactivity if your experiment targets specific variants; monoclonal origin ensures lot-to-lot consistency.
• Consider parallel testing with isotype controls and biological replicates to ensure robust data.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with a seamless supply chain for IVD raw materials, from optimized monoclonal antibodies like this TRAIL-R2 conjugate to validated antibody pairs and bulk ancillary reagents. This anti-CD262/DR5/TRAILR2 antibody supports flow cytometry applications in apoptosis and cancer research. Partner with CamelBio to accelerate your diagnostic development with reliable, one-stop sourcing.