Rabbit anti-Human CD206/MMR Monoclonal Antibody for FC - P22897

Core Product Specifications and Parameters

Biological Background: Macrophage Mannose Receptor 1 (CD206) Function and Localization

• MRC1 encodes Macrophage mannose receptor 1 (MMR/CD206), a type I transmembrane glycoprotein of the C-type lectin family, also known as CLEC13D or hMR.
• Functions as an endocytic receptor on macrophages, binding sulfated and non-sulfated polysaccharide chains to mediate clearance of glycoproteins.
• Serves as a phagocytic receptor for bacteria, fungi, and other pathogens, facilitating innate immune recognition.
• Acts as a cellular receptor for viral entry, including Dengue virus envelope protein E and Hepatitis B virus envelope protein.
• Localizes to the cell membrane and endosome membrane, supporting ligand internalization and recycling.
• Key structural features include an N-terminal cysteine-rich domain, fibronectin type II repeats, multiple C-type lectin domains, and a transmembrane helix.
• Undergoes alternative splicing; annotated with post-translational modifications including disulfide bonds and glycosylation (UniProt keywords: Glycoprotein, Disulfide bond).

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant fusion protein spanning amino acids 19-1389 of human CD206 (NP_002429.1), covering nearly the full extracellular region; thus, this antibody likely recognizes the native epitope.
• For flow cytometry, consider titrating the antibody on human macrophage or dendritic cell lines (e.g., THP-1, U937, or primary PBMC-derived macrophages) to determine optimal staining concentration.
• Since CD206 is expressed on M2-polarized macrophages and dendritic cells, include appropriate controls (e.g., M1-polarized macrophages) to assess specificity.
• Fluorophore is compatible with standard FITC/GFP channels; use appropriate isotype controls and viability dyes.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing. For CD206-related research in immune cell profiling, infectious disease, or cancer immunotherapy, we offer comprehensive supply solutions tailored to your development pipeline.