Rabbit anti-Human CD201/EPCR Monoclonal Antibody for Flow Cytometry - Q9UNN8

Core Product Specifications and Parameters

Biological Background: CD201/EPCR Function and Localization

• CD201/EPCR (endothelial protein C receptor) is encoded by the PROCR gene and is also known as activated protein C receptor (APC receptor).
• It binds activated protein C and enhances protein C activation by the thrombin-thrombomodulin complex, playing a critical role in the protein C anticoagulant pathway.
• The receptor is a transmembrane glycoprotein with a disulfide bond, localized to the plasma membrane.
• EPCR is expressed strongly in endothelial cells of arteries and veins in heart and lung, less intensely in capillaries of lung and skin, and is absent from endothelium of small vessels in liver and kidney.
• As a key component of the blood coagulation and hemostasis systems, EPCR helps regulate thrombin generation and fibrinolytic responses.
• The protein undergoes post-translational modifications including glycosylation and disulfide bond formation, which are important for its structure and function.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 18–210) covers the extracellular domain, making this antibody suitable for detecting native cell-surface CD201/EPCR by flow cytometry.
• is a bright, photostable fluorophore; consider titrating the antibody and using appropriate isotype controls in your flow cytometry panel.
• Validate in relevant human endothelial cell systems (e.g., HUVECs or primary endothelial cells from heart/lung) due to the tissue-specific expression pattern.
• For multi-color flow cytometry, ensure spectral separation with other fluorophores and check for compensation requirements.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with comprehensive access to IVD raw materials, from validated antibody pairs and optimized monoclonal antibodies to bulk ancillary reagents, supporting your projects from concept to clinic. For blood coagulation targets like CD201/EPCR, we can assist with sourcing rare and custom antibodies tailored to your assay development needs. Reach out to explore how our one-stop raw material solutions can accelerate your hemostasis research and diagnostic kit development.