Rabbit anti-Human CD201/EPCR Monoclonal Antibody for Flow Cytometry - Q9UNN8

Core Product Specifications and Parameters

Biological Background: CD201/EPCR Function and Localization

• CD201/EPCR, also designated activated protein C receptor (APC receptor) or endothelial cell protein C receptor, is a transmembrane receptor encoded by the PROCR gene.
• It binds activated protein C and enhances its activation by the thrombin-thrombomodulin complex, playing a central role in the protein C anticoagulant pathway that controls blood coagulation.
• The protein is localized to the cell membrane, with strong expression on the endothelial cells of arteries and veins in the heart and lung, lower expression in capillaries of the lung and skin, and absence in the endothelium of small vessels in the liver and kidney.
• As a glycoprotein, it possesses disulfide bonds and is implicated in hemostasis; its structure has been solved, and it is part of the reference proteome.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (amino acids 18-210) of human CD201/EPCR, encompassing the ligand-binding region; this design supports recognition of the native receptor on the cell surface, making the antibody compatible with flow cytometry applications.
• For flow cytometry, titrate the antibody to determine the optimal concentration for your cell type and instrument, and consider including appropriate isotype controls to assess non‑specific binding.
• Verify expression of human CD201/EPCR in your target cell population (e.g., endothelial cells) using complementary techniques, as staining intensity may vary with cell type and activation state.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research institutes by providing a trusted one-stop supply of IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. This product targets CD201/EPCR, relevant to coagulation and hemostasis research, and exemplifies our capability to source specialized reagents. Our streamlined procurement bridges the gap from concept to clinic, helping you secure rare‑target raw materials efficiently.