Rabbit Anti-Human CD2 Monoclonal Antibody for FC - P06729

Core Product Specifications and Parameters

Biological Background: CD2 Function and Localization

• CD2 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily, serving as a T-cell surface antigen involved in cell adhesion and signaling.
• It mediates adhesion between T-cells and antigen-presenting cells or target cells by binding to CD58 (LFA-3) and CD48/BCM1.
• The cytoplasmic domain of CD2 participates in T-cell activation and signal transduction upon ligand engagement.
• CD2 is localized at the cell membrane as a single-pass type I membrane protein.
• Expression is predominantly found on T-cells and natural killer (NK) cells, as confirmed at the protein level.
• Post-translational modifications include glycosylation and the formation of a conserved disulfide bond within its Ig-like domain.

Experimental Guidance and Technical Tips

• The immunogen covers the extracellular region (aa 25-209), which is suitable for detecting cell surface CD2 in live-cell flow cytometry.
• For optimal results, validate the antibody with appropriate isotype controls and use a known positive cell line such as Jurkat or primary T cells.
• Since CD2 is a glycoprotein, consider the potential impact of glycosylation on epitope accessibility in different cell types.

CamelBio: Your One-Stop Sourcing Bridge

As a leading provider of IVD raw materials, CamelBio supports diagnostic developers with high-quality antibodies like this anti-CD2 clone, ideal for immune cell profiling and diagnostics. Beyond monoclonal antibodies, we offer validated antibody pairs, bulk reagents, and custom sourcing for rare targets to accelerate your assay development from concept to clinic.